The Most Significant Publications

CAPRIOGLIO, D.; MATTOTEIA, D.; MUÑOZ, E.; TAGLIALATELA-SCAFATI, O.; APPENDINO, G. One-pot oxidative heterofunctionalisation of resorcinolic cannabinoids to non-thiophilic aminocannabinoquinones. European Journal of Organic Chemistry, 2022, 6.

MATTOTEIA, D.; SCHIANO MORIELLO, A.; TAGLIALATELA-SCAFATI, O.; et al. The combined effect of branching and elongation on the bioactivity profile of phytocannabinoids. Part I: Thermo-TRPs. Biomedicines, 2021, 9(8): 107.

MATTOTEIA, D.; TAGLIALATELA-SCAFATI, O.; MUÑOZ, E.; et al. Regiodivergent synthesis of ortho- and para-cannabinoquinones. European Journal of Organic Chemistry, 2020, 48: 7429–7434.

CAPRIOGLIO, D.; MATTOTEIA, D.; MINASSI, A.; et al. One-pot total synthesis of cannabinol via iodine-mediated deconstructive annulation. Organic Letters, 2019, 21(15): 6122–6125.

CAPRIOGLIO, D.; FLETCHER, S.P. An alternative synthesis of the breast cancer drug fulvestrant: catalyst control over C–C bond formation. Chemical Communications, 2015, 51(80): 14866–14868.

Professional Activities

Teaching Activities

Teaching Organic Chemistry, Preparatory Laboratory of Chemistry and Chemistry of Biomolecules within Biotechnology, Pharmacy and Pharmaceutical Chemistry and Technology programmes at the University of Eastern Piedmont.

Teaching doctoral courses in Bioorganic Chemistry and the history and impact of biologically active molecules.

Supervision and co-supervision of more than 60 experimental theses and four PhD theses in the chemistry of natural compounds.

Previous teaching assistance in Pharmaceutical Analysis, Phytochemistry and Herbal Preparations.

Research Activities

Research focused on natural substances, their chemical composition, biological activity and potential applications in medicine, agriculture and environmental science.

Organic synthesis and semi-synthesis of bioactive natural compounds, including cannabinoids, curcuminoids, triterpenoids and phenolic compounds.

Investigation of cannabinoids in inflammatory and neurodegenerative diseases and development of new anti-inflammatory, antitumour and imaging agents.

Isolation, purification and structural characterisation of natural products using NMR, LC-MS, IR and HPLC techniques.

Development of synthetic approaches involving organometallic reagents, microwave reactors and photochemical reactors.

Research Collaborations and Projects

Long-term collaborations with research groups at the University of Naples Federico II, the University of Córdoba, the National Research Council of Italy, the University of Jena and international biotechnology companies.

Participation in the European TriForC project and the PRIN project dedicated to the exploration of the phytocannabinoid chemical space.

Co-Principal Investigator of a University of Eastern Piedmont project concerning the development of a biosensor for collagen degradation.

Academic and Outreach Activities

Department Coordinator for UPOJunior and former Coordinator for the European Researchers’ Night.

Responsible for the organisation of the Departmental Seminar Series at the Department of Pharmaceutical Sciences.

Participation in science-communication initiatives for schools and the general public.

Invited speaker at national and international conferences on cannabinoid chemistry and bioactive natural products.

Editorial and Professional Activities

Member of the Italian Chemical Society, Piedmont and Aosta Valley Section.

Honorary Member of the Argentine Society for Research in Organic Chemistry.

Guest Editor of a Frontiers special issue on cannabinoids and related meroterpenoids.

Reviewer for scientific journals in organic chemistry and natural-products chemistry.

Author of a patent concerning a probe targeting the ALDH1A3 enzyme for glioblastoma diagnosis.